Rose suffered a shin wound at the end of Sunday’s 3-1 victory over Leicester, being withdrawn in the 88th minute, and the club are assessing whether he will even make the squad.
“Tomorrow it’s impossible for him to start from the beginning,” Pochettino told a news conference. “Tomorrow we’re going to assess whether he can be on the bench.”
Spurs’ other left-back, Ben Davies, is out after missing Tuesday’s training session.
The Welshman, who trained by himself on Tuesday, has missed the last four matches with a groin problem and is not yet ready to return.
As a result, Vertonghen is likely to step in, as he did when Spurs beat Newcastle 1-0 earlier this month. The Belgium international has regularly played in that role for his country.